When was AZT first used?
AZT (zidovudine) In March of 1987, FDA approved zidovudine (AZT) as the first antiretroviral drug for the treatment of AIDS..
Who should not take zidovudine?
increased blood acidity due to high levels of lactic acid. anemia. low levels of a type of white blood cell called neutrophils. a disease with shrinking and weaker muscles called myopathy.
When should I take zidovudine?
Zidovudine should be given twice each day. If you remember up to 6 hours after you should have given a dose, give your child the missed dose. For example, if you usually give a dose at about 7 am, you can give the missed dose at any time up to 1 pm.
How is zidovudine taken?
Zidovudine comes as a capsule, tablet, and syrup to take by mouth. It is usually taken twice a day by adults and two to three times a day by infants and children. Infants 6 weeks of age and younger may take zidovudine every 6 hours. When zidovudine is taken by pregnant women, it may be taken 5 times a day.
Is AZT good or bad?
Scientists quickly injected AZT into patients. The first goal was to see whether it was safe — and, though it did cause side effects (including severe intestinal problems, damage to the immune system, nausea, vomiting and headaches) it was deemed relatively safe. But they also had to test the compound’s effectiveness.
Is zidovudine still used?
Zidovudine, also known as azidothymidine (AZT), was the first antiviral to be approved for the treatment of HIV. Although no longer a first-line agent, zidovudine is still used in combination with other ARVs for the treatment of HIV .
Why was AZT so expensive?
Drug companies deserve high profits on new drugs to encourage invention and risk-taking. What makes the cost of AZT hard to swallow is that all the invention and much of the risk was undertaken by the Federal Government. The average cost of bringing a new drug to market is $125 million.
What are the side effects of AZT?
Side effects. Common side effects that have been reported by some AZT users include headaches, nausea, vomiting, insomnia, tiredness, muscle pain, and loss of appetite. Many people find that side effects caused by anti-HIV drugs improve or go away after the first several weeks of treatment.
Did AZT save lives?
Mortality rates for people taking AZT were staggeringly lower than those taking the placebo; there had been 19 deaths in the placebo group of 137 people, but only one in the AZT group of 145. Those on AZT also had a decreased number of opportunistic infections and showed improvement in weight gain and T4 cell counts.
What is AZT to which use is it being put?
AZT, in full azidothymidine, also called zidovudine, drug used to delay development of AIDS (acquired immunodeficiency syndrome) in patients infected with HIV (human immunodeficiency virus). …