Question: What Does IVIG Stand For?

Does IVIg help autoimmune disease?

For years, doctors have used IVIG to treat patients with autoimmune and chronic inflammatory diseases, such as dermatomyositis, Kawasaki disease, multiple sclerosis, lupus, chronic lymphocytic leukemia, and idiopathic thrombocytopenic purpura, but just how the therapy works has remained a mystery..

How effective is IVIG treatment?

A number of randomized controlled trials have shown that IVIG is effective in acute and chronic demyelinating neuropathies, in worsening MG as short-term therapy, in certain inflammatory myopathies, and in stiff-person syndrome (Table ​ 1).

What is IVIG used to treat?

In immunology IVIG is used in the treatment of primary antibody deficiency (PAD), in nephrology, rheumatology and ophthalmology it has been used to treat vasculitis, systemic lupus erythematosis (SLE), mucous membrane pemphigoid and uveitis and in dermatology it is used most commonly to treat Kawasaki syndrome, …

Does IVIg cause hair loss?

IVIG has caused eczematous dermatitis and alopecia. Complement consumption associated with an eczematous cutaneous reaction has been noted during infusions of high doses of IVIG.

Does IVIg help inflammation?

When administered at a high dose, IVIg inhibits inflammation and has proven efficacy in the treatment of various autoimmune and systemic inflammatory diseases. Importantly, IVIg therapy can ameliorate both auto-antibody-mediated and T-cell mediated immune pathologies.

How do you feel after IVIg infusion?

With IVIG, you may develop a headache during or after your infusion. Some people also feel cold during the infusion and often ask for a blanket. You may also feel more tired or have muscle aches or fever after your infusion and need to rest for a day before feeling like your usual self.

How long does IVIG last in the body?

IVIg should start to work within a few weeks, but this will vary depending on which condition you have and how you respond to the treatment. If IVIg works for you, the effects should last for a few months.

Is IVIG an immunosuppressant?

In consensus with the experimental evidence, IVIG administration has been shown to expand the production of these immunosuppressive cells in patients with Kawasaki disease, systemic lupus erythematosus (SLE), eosinophilic granulomatosis with polyangiitis, and Guillain–Barré syndrome [26–30].

How many IVIG treatments do I need?

IVIG doses range from 400 to 800 mg/kg/month are used for immune deficiencies. Doses may be given every three to four weeks. In patients who require auto-inflammatory effects of IVIG, high doses are typically required. This will usually range from 1-2 g/kg as a single dose.

Why is IVIG so expensive?

Controversy: Due to its high cost of manufacturing and administering the product, IVIG is an expensive therapy. The total cost of IVIG therapy ranges from $5000 to $10,000, depending on the patient’s weight and number of infusions per course. Additional costs may include a hospital stay if home infusion is not covered.

Can IVIg cause weight gain?

If you take GAMUNEX-C or a similar immune globulin product intravenously, you could experience serious kidney disease and death. You may have symptoms of decreased urination, sudden weight gain, swelling in your legs (edema), or shortness of breath.

Does Medicare pay for IVIG infusions?

Medicare Part B is a medical benefit and allows coverage for intravenous immunoglobulin replacement therapy (IVIG) because it was typically administered in a hospital or facility setting. CMS makes medical determinations as to the PI diagnoses that are covered under Part B for home infusions.

What are the risks of IVIG?

The majority of these events, such as flushing, headache, malaise, fever, chills, fatigue and lethargy, are transient and mild. However, some rare side effects, including renal impairment, thrombosis, arrhythmia, aseptic meningitis, hemolytic anemia, and transfusion-related acute lung injury (TRALI), are serious.

Does IVIg affect blood work?

We conclude that IVIG affects a variety of serum chemistry and hematological values either directly or artifactually by interfering with the laboratory method used for the assays. Transient lymphopenia is consistently seen, and may play a role in the immunomodulating effect of IVIG.

Can IVIG cause liver damage?

Elevation of liver enzymes may possibly be associated with certain IVIg preparations. Bearing these complications in mind, this prospective study supports the notion that IVIg can generally be regarded as safe, leading to severe adverse events during only 3 (0.9%) of 341 infusions (or 3 of 84 treatment courses, 3.6 %).